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KMID : 0603520000050010031
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 1 p.31 ~ p.38
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Antitumorigenic and Immunologic Effects of Kale Extracts and Chlorophyllin on Sarcoma 180 Cell-Transplanted Mice
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Lee Sun-Mi
Kim Kwang-Hyuk
Lee Sook-Hee
Park Kun-Young
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Abstract
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In the present study, we examined tumor formation on sarcoma 180 cells-transplanted Balb/c mice, and phagocytic activity, nitroblue tertazolium (NBT) reduction rate and nitric oxide (NO) production on the Balb/c mice by the treatment of kale juice, kale methanol extract and chlorophyllin. The kale (Brassica oleracea var. acephala) juice, kale methanol extract and chlorophyllin decreased the growth of sarcoma 180 cells in vitro and inhibited the tumor formation by 67.9%, 71.0% and 61.9% compared to the control on sarcoma 180 cell transplanted Balb/c mice, respectively. The phagocytic activity and NBT reduction rate in peritoneal phagocytic cells of the Balb/c mice were considerably increased by the treatment of the kale extracts and chlorophyllin in comparison with the control group, however, no significant changes were observed by the treatments in the No production.
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KEYWORD
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Kale, Chlorophyllin, Antitumor, Immunologic effect
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